nucВестник НЯЦ РКNNC RK Bulletin1729-75161729-7885Национальный ядерный центр Республики Казахстан10.52676/1729-7885-2020-2-61-69nuc-242Research ArticleСтатьиВЛИЯНИЕ ИТЕРАЦИОННЫХ АЛГОРИТМОВ НА КАЧЕСТВО ИЗОБРАЖЕНИЯ И ПОЛУКОЛИЧЕСТВЕННЫЕ ХАРАКТЕРИСТИКИ НАКОПЛЕНИЯ РФПINFLUENCE OF ITERATIVE ALGORITHMS ON IMAGE QUALITY AND SEMI-QUANTITATIVE CHARACTERISTICS OF RADIOPHARMACEUTICALЕмельяненкоЕ. В.EmelyanenkoE.

Минск

Minsk

zheka-ava@mail.ruТарутинИ. Г.TarutinI.

Минск

Minsk

ДзюбанА. В.DzyubanA.

Минск

Minsk

РНПЦ онкологии и медицинской радиологии им. Н.Н. АлександроваБеларусьN.N. Alexandrov National Cancer Centre of BelarusBelarus202030062020026169Copyright © Емельяненко Е.В., Тарутин И.Г., Дзюбан А.В., 20202020Емельяненко Е.В., Тарутин И.Г., Дзюбан А.В.Emelyanenko E., Tarutin I., Dzyuban A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journals.nnc.kz/jour/article/view/242

Исследовано влияние параметров итерационных алгоритмов реконструкции, использующихся в позитронно-эмиссионной томографии, на полуколичественные показатели и качество диагностического изображения в клинических условиях. Получены функции зависимости стандартизированного показателя накопления и метаболического объема от количества итераций и подмножеств. Рассмотрены особенности влияния итерационных алгоритмов реконструкции на образования размером 6 мм. Исследованы 10 пациентов, проведено их сканирование с использованием итерационного алгоритма VPHD c включенной PSF функцией, времяпролетной технологией TOF. Проанализировано влияние указанных параметров сканирования на контраст, шум и соотношение сигнал/шум. Представлены графики зависимости полуколичественных характеристик от количества итераций и подмножеств. Произведена оценка изменения полуколичественных значений накопления радиофармацевтического препарата при варьировании диапазона итераций. Предложены методы оптимизации диагностических протоколов сканирования пациентов. Выполнена проверка полученных результатов на примере диагностического изображения.

The influence of parameters of iterative reconstruction algorithms used in positron emission tomography on semi-quantitative indicators and the quality of a diagnostic image in a clinical setting is investigated. The functions of the dependence of the standardized accumulation index and metabolic volume on the number of iterations are obtained. Peculiarities of the influence of iterative reconstruction algorithms on formations with a size of 6–8 mm are considered. We examined 10 patients scanned using the iterative VPHD algorithm with the PSF function turned on, time-of-flight TOF technology using the PSF function. The influence of the indicated scanning parameters on contrast, noise, and signal-to-noise ratio is analyzed. Graphs of the dependence of semi-quantitative characteristics on the number of iterations and subsets are presented. The change in semiquantitative values was estimated by varying the range of iterations and subsets. Methods for optimizing diagnostic protocols for scanning patients are proposed.

итерацияподмножествостандартизированный показатель накопленияшумконтрастiterationsubsetstandardized accumulation indexnoisecontrastReferencesRecent developments in time-of-flight PET / S. Vandenberghe [et al.] // EJNMMI Phys. – 2016. – Vol. 3, № 1. – P. 3.Recent developments in time-of-flight PET / S. Vandenberghe [et al.] // EJNMMI Phys. – 2016. – Vol. 3, № 1. – P. 3.Iterative reconstruction algorithms in nuclear medicine / S. Vandenberghe [et al.] // Computerized Medical Imaging and Graphics. – 2001. – Vol. 25, № 2. – P. 105–111.Iterative reconstruction algorithms in nuclear medicine / S. Vandenberghe [et al.] // Computerized Medical Imaging and Graphics. – 2001. – Vol. 25, № 2. – P. 105–111.Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET / C.S. van der Vos [et al.] // Eur J Nucl Med Mol Imaging. – 2017. – Vol. 44, № S1. – P. 4–16.Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET / C.S. van der Vos [et al.] // Eur J Nucl Med Mol Imaging. – 2017. – Vol. 44, № S1. – P. 4–16.Comparison among Reconstruction Algorithms for Quantitative Analysis of 11 C-Acetate Cardiac PET Imaging / X. Shi [et al.] // Contrast Media & Molecular Imaging. – 2018. – Vol. 2018 – P. 1–10.Comparison among Reconstruction Algorithms for Quantitative Analysis of 11 C-Acetate Cardiac PET Imaging / X. Shi [et al.] // Contrast Media & Molecular Imaging. – 2018. – Vol. 2018 – P. 1–10.Standard OSEM vs. regularized PET image reconstruction: qualitative and quantitative comparison using phantom data and various clinical radiopharmaceuticals / J. Lantos [et al.] – P. 9.Standard OSEM vs. regularized PET image reconstruction: qualitative and quantitative comparison using phantom data and various clinical radiopharmaceuticals / J. Lantos [et al.] – P. 9.Benefit of Time-of-Flight in PET: Experimental and Clinical Results / J.S. Karp [et al.] // Journal of Nuclear Medicine. – 2008. – Vol. 49, № 3. – P. 462–470.Benefit of Time-of-Flight in PET: Experimental and Clinical Results / J.S. Karp [et al.] // Journal of Nuclear Medicine. – 2008. – Vol. 49, № 3. – P. 462–470.Feasibility of state of the art PET/CT systems performance harmonisation / A. Kaalep [et al.] // Eur J Nucl Med Mol Imaging. – 2018. – Vol. 45, № 8. – P. 1344–1361.Feasibility of state of the art PET/CT systems performance harmonisation / A. Kaalep [et al.] // Eur J Nucl Med Mol Imaging. – 2018. – Vol. 45, № 8. – P. 1344–1361.Alessio, A.M. Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priors / A.M. Alessio, P.E. Kinahan // Med Phys. – 2006. – Vol. 33, № 11. – P. 4095–4103.Alessio, A.M. Improved quantitation for PET/CT image reconstruction with system modeling and anatomical priors / A.M. Alessio, P.E. Kinahan // Med Phys. – 2006. – Vol. 33, № 11. – P. 4095–4103.Optimization of PET/CT image quality using the GE “Sharp IR” point-spread function reconstruction algorithm / N.J. Vennart [et al.] // Nuclear Medicine Communications. – 2017. – Vol. 38, № 6. – P. 471–479.Optimization of PET/CT image quality using the GE “Sharp IR” point-spread function reconstruction algorithm / N.J. Vennart [et al.] // Nuclear Medicine Communications. – 2017. – Vol. 38, № 6. – P. 471–479.

The authors declare that there are no conflicts of interest present.