nucВестник НЯЦ РКNNC RK Bulletin1729-75161729-7885Национальный ядерный центр Республики Казахстан10.52676/1729-7885-2024-3-137-143nuc-714Research ArticleСтатьиВЛИЯНИЕ МЕРКАПТОПРОПИЛТРИМЕТОКСИСИЛАНА НА ХИМИЧЕСКОЕ ОСАЖДЕНИЕ МИКРОТРУБОК ЗОЛОТА В ТРЕКОВЫЕ МЕМБРАНЫ И ИСПОЛЬЗОВАНИЕ ИХ В СЕНСОРИКЕINFLUENCE OF MERCAPTOPROPYLTRIMETHOXYSILANE ON THE CHEMICAL DEPOSITION OF GOLD MICROTUBES IN TRACK-ETCHED MEMBRANES AND THEIR APPLICATION IN SENSOR TECHNOLOGYШакаеваА. Х.ShakayevaA. Kh.

Алматы

Астана

Almaty

Astana

shakayevaa19@gmail.comКорольковИ. В.KorolkovI. V.

Алматы

Астана

Almaty

Astana

i.korolkov@inp.kzЖуманазарН.ZhumanazarN.

Алматы

Almaty

n.zhumanazar@inp.kzНурпеисоваД. Т.NurpeisovaD. T.

Астана

Astana

dinara_1808@mail.ruЗдоровецМ. В.ZdorovetsM. V.

Алматы

Астана

Almaty

Astana

mzdorovets@inp.kzРГП «Институт ядерной физики» МЭ РК; Евразийский национальный университет им. Л.Н. ГумилеваКазахстанRSE “Institute of Nuclear Physics” ME RK; L.N. Gumilyov Eurasian National UniversityKazakhstanРГП «Институт ядерной физики» МЭ РККазахстанRSE “Institute of Nuclear Physics” ME RKKazakhstanЕвразийский Национальный университет имени Л.Н. ГумилеваКазахстанL.N. Gumilyov Eurasian National UniversityKazakhstan20243009202403137143Copyright © Шакаева А.Х., Корольков И.В., Жуманазар Н., Нурпеисова Д.Т., Здоровец М.В., 20242024Шакаева А.Х., Корольков И.В., Жуманазар Н., Нурпеисова Д.Т., Здоровец М.В.Shakayeva A.K., Korolkov I.V., Zhumanazar N., Nurpeisova D.T., Zdorovets M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journals.nnc.kz/jour/article/view/714

Диабет является одной из глобальных проблем здравоохранения, требующий создания надежных и точных устройств для мониторинга уровня глюкозы в крови. В данном исследовании был разработан неферментативный сенсор на основе модифицированной полиэтилентерефталатной трековой мембраны (ПЭТФ ТМ) для электрохимического определения глюкозы. Впервые была применена модификация мембраны с использованием меркаптопропилтриметоксисилана (МПТМС) с целью улучшения адгезии микроструктур золота и повышения эффективности процесса химического осаждения. Модификация позволила значительно увеличить площадь поверхности сенсора до 0,91±0,25 см2. Вольтамперометрические измерения показали линейную зависимость между плотностью тока и концентрацией глюкозы в диапазоне от 0,1 до 16 мМ, предел обнаружения сенсоров Au@ПЭТФ ТМ-МПТМС составил 0,058 мМ. Разработанные сенсоры демонстрируют хорошую чувствительность и высокую стабильность, что расширяет их потенциальное применение в биосенсорике.

Diabetes is one of the global healthcare problems requiring the development of reliable and accurate devices for monitoring blood glucose levels. In this study, a non-enzymatic sensor based on a modified poly(ethylene terephthalate) track-etched membrane (PET TeMs) was developed for the electrochemical detection of glucose. For the first time, membrane modification using mercaptopropyltrimethoxysilane (MPTMS) was applied to improve the adhesion of gold nanostructures and enhance the efficiency of the gold electroless deposition process. The modification significantly increased the sensor real surface area to 0.91±0.25 cm². Voltammetric measurements showed a linear dependence between the current density and glucose concentration in the range of 0.1 to 16 mM, with a detection limit of 0.058 mM for PET TeMs/MPTMS@Au sensors. The developed sensors demonstrate good sensitivity and high stability, broadening their potential application in biosensing.

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The authors declare that there are no conflicts of interest present.