Preview

NNC RK Bulletin

Advanced search

DETERMINATION OF THE BACKGROUND FREQUENCY OF UNSTABLE ABERRATIONS FOR THE DOSE ZERO POINT IN DIFFERENT REGIONS OF KAZAKHSTAN

https://doi.org/10.52676/1729-7885-2020-2-119-127

Abstract

he article gives research into the regional background frequency of unstable aberrations in residents of the main regions of Kazakhstan (North, South, West, East). This parameter as the dose reference “zero” point has a large percentage of uncertainty and is variable. Cities of regional importance were chosen by the biggest population size and its ethnic diversity. In each region a group of indigenous inhabitants was created – 10 volunteers in number. The groups were ranked by age and sex in the ratio of 1:1 (a total of 40 people). The background frequency for unstable chromosome damages was calculated by means of an automated cytogenetic platform on the basis of the Carl Zeiss AxioImager Z2 electronic fluorescent microscope, the automatic metaphase search and analysis system Metafer 4/M Search, ICAROS (MetaSystems, Germany). Research observations demonstrate an interregional variability of aberrant cells per 1,000 between 1.1±0.4 and 3.09±0.6, which can be attributable to a variety of human and objective factors of life activity.

About the Authors

L. B. Kenzhina
Branch “Institute of Radiation Safety and Ecology” RSE NNC RK
Kazakhstan
Kurchatov


A. N. Mamyrbayeva
Branch “Institute of Radiation Safety and Ecology” RSE NNC RK
Kazakhstan
Kurchatov


A. О. Kenesarina
Branch “Institute of Radiation Safety and Ecology” RSE NNC RK
Kazakhstan
Kurchatov


References

1. Использование цитогенетической дозиметрии для обеспечения готовности и реагирования при радиационных аварийных ситуациях. Международное агентство по атомной энергии – Вена – 2014. – IAEA.

2. Blakely W.F., Carr Zh. WHO 1st consultation on the development of a global biodosimetry laboratories network for radiation emergencies (BioDoseNet) / Blakely W.F., Carr Zh., Chu M.C., Dayal-Drager R., Fujimoto K., Hopmeir M., Kulka U., Lillis-Hearne P., Livingston G.K., Lloyd D.C., Maznyk N., Perez Mdel R., Romm H., Takashima Y., Voisin P., Wilkins R.C., Yoshida M.A. // Radiat. Res. – 2009. – № 171(1) – Р. 127–139.

3. Общие процедуры медицинского реагирования при ядерной или радиологической ситуации. Международное агентство по атомной энергии – Вена – 2019. – IAEA.

4. Конвенция об оперативном оповещении о ядерной аварии, и Конвенция о помощи в случае ядерной аварии или радиационной аварийной ситуации. Серия по юридическим вопросам № 14, Международное агентство по атомной энергии – Вена – 1990. – IAEA.

5. Harrison J., Fell T. The polonium-210 poisoning of Mr. Alexander Litvinenko / Harrison J., Fell T., Leggett R., Lloyd D., Puncher M., Youngman M. // J. Radiol. Prot. – 2017 – № 37 (1). – Р. 266–278.

6. Thierens H. Cytogenetic biodosimetry of an accidental exposure of a radiological worker using multiple assays // Thierens H., De Ruyck K., Vral A., de Gelder V., Whitehouse C.A., Tawn E.J., Boesman I. // Rad. Protect. Dosimetry. – 2005. – V. 113(4). – P. 408–414.

7. Balajee A.S. Development of electronic training and telescoring tools to increase the surge capacity of dicentric chromosome scorers for radiological/nuclear mass casualty incidents. / Balajee A.S, Escalona M., Iddins C.J, Shuryak I., Livingston G.K., Hanlon D., Dainiak N. // Appl. Radiat. Isot. – 2019. - №144. – Р.111-117.

8. Kulka U. RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry. / Kulka U., Abend M., Ainsbury E., Badie C., Barquinero J.F., Barrios L., Beinke C., Bortolin E., Cucu A., et all. // Int. J. Radiat. Biol. – 2017 – № 93 (1) – Р. 2–14.

9. Garcia O. The Latin American Biological Dosimetry Network (LBDNet). / Garcia O., Di Giorgio M., Radl A., Taja M.R., Sapienza C.E., Deminge M.M., Fernandez Rearte J., Stuck Oliveira M., Valdivia P., Lamadrid A.I., Gonzalez J.E., Romero I., Mandina T., Guerrero-Carbajal C., Arceo Maldonado C., Cortina Ramirez G.E., Espinoza M., Martinez-Lopez W., Di Tomasso M.// Radiat. Prot. Dosimetry. – 2016. – № 171. – Р. 64–69.

10. Ruth C. Wilkins. Evaluation of the annual Canadian biodosimetry network intercomparisons. // Ruth C. Wilkins, Lindsay A. Beaton-Green, Sylvie Lachapelle, Barbara C. Kutzner, Catherine Ferrarotto, Vinita Chauhan, Leonora Marro, Gordon K. Livingston, Hillary Boulay Greene, Farrah N. Flegal. // Int. J. Radiat. Biol. – 2015. - №91(5). – P. 443–451.

11. U. Kulka U. Biodosimetry and biodosimetry networks for managing radiation emergency. / Kulka, A. Wojcik, M. Di Giorgio, R. Wilkins, Y. Suto, S. Jang, L. Quing-Jie, L. Jiaxiang, E. Ainsbury, C. Woda, L. Roy, C. Li, D. Lloyd and Z. Carr // Radiation Protection Dosimetry. – 2018 - №137. – Р. 1–11

12. Soumboundou M. Biological Dosimetry Network in Africa: Establishment of a Dose-response Curve Using Telomere and Centromere Staining. // Soumboundou M., Nkengurutse I., Dossou J., Colicchio B., Djebou C., Gadji M., Houenon G., Dem A., Dedjan A., Diarra M., Adjibade R., Finot F., Hempel W., Dieterlen A., Jeandidier E., Rodriguez-Lafrasse C., M'kacher R. // Health Phys. – 2019.

13. Dainiak N. Concepts of operations for a us dosimetry and biodosimetry Network. / Dainiak N., Albanese J., Kaushik M., Balajee A.S., Romanyukha A., Sharp T.J., Blakely W.F. // Radiat. Prot. Dosimetry. – 2019.

14. Севанькаев А.В. Сравнительный анализ результатов цитогенетических обследований контрольных групп лиц в различных отечественных лабораториях. // Севанькаев А.В., Хвостунов И.К., Снигирёва Г.П. и соавт. // Радиац. биол. Радиоэкология. – 2013. – Т. 53. – № 1. – С. 5–24.

15. Wilkins R. C. Interlaboratory Comparison of the Dicentric Chromosome Assay for Radiation Biodosimetry in Mass Casualty Events. // Wilkins R.C., Romm H., Kao T.C., Awa A.A., Yoshida M.A., Livingston G.K., Prasanna P. G. // Radiation Research. – 2008. – № 169 (5). – P. 551–560.

16. Aseeva E.A. New type of cells with multiple chromosome rearrangements. / Aseeva E.A., Snigiryova G.P., Neverova A.L., Bogomazova A.N., Novitskaya N.N., Khazins E.D., Domracheva E.V.// Appl. Radiat. Isot. – 2010 - № 68(4-5). – P. 844–847.


Review

For citations:


Kenzhina L.B., Mamyrbayeva A.N., Kenesarina A.О. DETERMINATION OF THE BACKGROUND FREQUENCY OF UNSTABLE ABERRATIONS FOR THE DOSE ZERO POINT IN DIFFERENT REGIONS OF KAZAKHSTAN. NNC RK Bulletin. 2020;(2):119-127. (In Russ.) https://doi.org/10.52676/1729-7885-2020-2-119-127

Views: 338


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1729-7516 (Print)
ISSN 1729-7885 (Online)