DETERMINATION OF THE BACKGROUND FREQUENCY OF UNSTABLE ABERRATIONS FOR THE DOSE ZERO POINT IN DIFFERENT REGIONS OF KAZAKHSTAN

he article gives research into the regional background frequency of unstable aberrations in residents of the main regions of Kazakhstan (North, South, West, East). This parameter as the dose reference “zero” point has a large percentage of uncertainty and is variable. Cities of regional importance were chosen by the biggest population size and its ethnic diversity. In each region a group of indigenous inhabitants was created – 10 volunteers in number. The groups were ranked by age and sex in the ratio of 1:1 (a total of 40 people). The background frequency for unstable chromosome damages was calculated by means of an automated cytogenetic platform on the basis of the Carl Zeiss AxioImager Z2 electronic fluorescent microscope, the automatic metaphase search and analysis system Metafer 4/M Search, ICAROS (MetaSystems, Germany). Research observations demonstrate an interregional variability of aberrant cells per 1,000 between 1.1±0.4 and 3.09±0.6, which can be attributable to a variety of human and objective factors of life activity.

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