МОНИТОРИНГ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ В ПОВЕРХНОСТНЫХ ВОДАХ ГОРОДА НУР-СУЛТАН И ЕГО ОКРЕСТНОСТЕЙ (РЕСПУБЛИКА КАЗАХСТАН)
Аннотация
В статье приведены данные мониторинга лекарственных веществ (ЛВ) в поверхностных водоемах города Нур-Султан и его окрестностей (Республика Казахстан). Результаты показывают присутствие карбамазепина и сульфаметаксазола в поверхностных водах. Образцы отбирали ежемесячно с апреля по декабрь 2021 года. Анализ ЛВ проводили с использованием метода высокоэффективной жидкостной хроматографии (ВЭЖХ). Возможной причиной присутствия лекарственных веществ в поверхностных водоемах является поступление их со сточными водами коммунально-бытовой сферы города Нур-Султан в поверхностные источники после очистки.
Ключевые слова
Об авторах
А. СатаеваКазахстан
Нур-Султан
А. Камал
Казахстан
Нур-Султан
А. Байменов
Казахстан
Нур-Султан
Т. Керим
Казахстан
Нур-Султан
Ж. Исаев
Казахстан
Нур-Султан
Д. Ким
Казахстан
Нур-Султан
В. Инглезакис
Великобритания
Глазго
Е. Архангельски
Казахстан
Нур-Султан
Список литературы
1. Daughton C.G., Ruhoy I.S. Environmental footprint of pharmaceuticals: The significance of factors beyond direct excretion to sewers // Environ. Toxicol. Chem. – 2009. – Vol. 28, No. 12. – P. 2495–2521.
2. Kolpin D.W. et al. Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance // Environ. Sci. Technol. – 2002. – Vol. 36, No. 6. – P. 1202–1211.
3. Carvalho, I. T., and Santos, L. Antibiotics in the aquatic environments: a review of the European scenario // Environ. Int. – 2016. Vol. 94. – P. 736–757. https://doi.org/10.1016/j.envint.2016.06.025
4. Grenni, P., Ancona, V., and Barra Caracciolo, A. Ecological effects of antibiotics on natural ecosystems: a review // Microchem. J. – 2018. – Vol. 136. – P. 25–39. https://doi.org/10.1016/j.microc.2017.02.006
5. Blanco, G., Junza, A., and Barrón, D. (2017). Occurrence of veterinary pharmaceuticals in golden eagle nestlings: unnoticed scavenging on livestock carcasses and other potential exposure routes. Sci. Total Environ. 586, 355– 361. doi: 10.1016/j.scitotenv.2017.02.023
6. Brausch John M.and Connors K.A. and B.B.W. and R.G.M. Human Pharmaceuticals in the Aquatic Environment: A Review of Recent Toxicological Studies and Considerations for Toxicity Testing // Reviews of Environmental Contamination and Toxicology. – 2012. – Vol. 218. – P. 1–99.
7. Domercq P., Praetorius A., Boxall A.B.A. Emission and fate modelling framework for engineered nanoparticles in urban aquatic systems at high spatial and temporal resolution // Environ. Sci. Nano. – 2018. – Vol. 5, No. 2. – P. 533–543.
8. Аus der Beek T. et al. Pharmaceuticals in the environment – Global occurrences and perspectives // Environ. Toxicol. Chem. – 2016. – Vol. 35, No. 4. – P. 823–835.
9. Patel M. et al. Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods // Chem. Rev. – 2019. – Vol. 119, No. 6. – P. 3510–3673.
10. Jørgensen S.E., Halling-Sørensen B. Drugs in the environment // Chemosphere. – 2000. – Vol. 40, No. 7. – P. 691–699.
11. Halley B.A., VandenHeuvel W.J.A., Wislocki P.G. Environmental effects of the usage of avermectins in livestock // Vet. Parasitol. – 1993. – Vol. 48, No. 1. – P. 109–125.
12. Kinney C.A. et al. Presence and distribution of waste-water-derived pharmaceuticals in soil irrigated with reclaimed water // Environ. Toxicol. Chem. – 2006. – Vol. 25, No. 2. – P. 317–326.
13. Sandor Z. et al. Potential effects of pharmaceuticals and their residues in aquatic environment // Stud. Univ. Vasile Goldis Arad, Ser. Stiint. Vietii. – 2012. – Vol. 22. – P. 247–255.
14. Gadipelly C. et al. Pharmaceutical Industry Wastewater: Review of the Technologies for Water Treatment and Reuse // Ind. & Eng. Chem. Res. – 2014. – Vol. 53, No. 29. – P. 11571–11592.
15. Pal P. Treatment and Disposal of Pharmaceutical Waste-water: Toward the Sustainable Strategy // Sep. Purif. Rev. Taylor & Francis. – 2018. – Vol. 47, No. 3. – P. 179–198.
16. Guo Y., Qi P.S., Liu Y.Z. A Review on Advanced Treatment of Pharmaceutical Wastewater // {IOP} Conf. Ser. Earth Environ. Sci. {IOP} Publishing. – 2017. – Vol. 63. – P. 12025.
17. Pilli S. et al. 13 – Treatment of wastewater containing pharmaceuticals: biological treatment // Current Developments in Biotechnology and Bioengineering / ed. Tyagi R.D. et al. Elsevier. – 2020. P. 463–520.
18. Национальный доклад о состоянии окружающей среды и об использовании природных ресурсов Республики Казахстан за 2020 год. https://www.gov.kz/memleket/entities/ecogeo/documents/details/243132?directionId=14790&lang=ru
19. Казгидромет. Бюллетень о состоянии окружающей среды. https://www.kazhydromet.kz/uploads/files_calendar/1766/file/62628da78d8e9na-sayt-russ-nur-sultanyanvar-2022.pdf
20. Доклад ВОЗ «Фармацевтические средства в питьевой воде». https://www.who.int/water_sanitation_health/emerging/info_sheet_pharmaceuticals/ru/
21. ГОСУДАРСТВЕННЫЙ СТАНДАРТ РЕСПУБЛИКИ КАЗАХСТАН. ВОДА ПИТЬЕВАЯ. Отбор проб. СТ РК ГОСТ Р 51593-2003. https://online.zakon.kz/Document/?doc_id=30015917&pos=22;-46#pos=22;-46
22. Straub, Jürg Oliver. Aquatic Environmental Risk Assessment for Human Use of the Old Antibiotic Sulfamethoxazole in Europe // Environmental Toxicology and Chemistry. – 2015. – Vol. 35, No. 4. P. 767–779. https://doi.org/10.1002/etc.2945
23. A.V. Pereira, Q.B. Cass. High-performance liquid chromatography method for the simultaneous determination of sulfamethoxazole and trimethoprim in bovine milk using an on-line clean-up column. https://doi.org/10.1016/j.jchromb.2005.08.006
24. Esin Sayar, Selma Sahin, Semsettin Cevheroglu, A Atilla Hincal. Development and validation of an HPLC method for simultaneous determination of trimethoprim and sulfamethoxazole in human plasma. https://doi.org/10.1007/s13318-010-0006-9
25. Plants Alok Bhandari, Larry I. Close, Wongee Kim, Robert P. Hunter, David E. Koch and Rao Y. Surampalli. Occurrence of Ciprofloxacin, Sulfamethoxazole, and Azithromycin in Municipal Wastewater Treatment. Practice Periodical of Hazardous, Toxic, and Radioactive Waste Management, 2008. https://doi.org/10.1061/ASCE1090-025X200812:4275
26. C. K. Johnston and G. H. Lester. A simple procedure for the determination of carbamazepine in plasma by high pressure-liquid chromatography // Annals of Clinical Biochemistry. – 1979. – Vol. 16. – P. 213–216
27. Namita S. Rajadhyaksha, Satish P. Jain, Purnima D. Amin. Carbamazepine: Stability Indicating HPLC Assay Method. https://doi.org/10.1080/00032710701583557
28. Predrag Lj Džodić, Ljiljana J. Ivanovi, Ana D. Proti, Mira L. Zeevi, Biljana M. Joci. Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form by Column High-Performance Liquid Chromatography // Journal of Aoac International. – 2010. – Vol. 93, No. 4, P. 1059–1068. https://doi.org/10.1093/jaoac/93.4.1059
29. Göbel, A., McArdell, C. S., Joss, A., Siegrist, H., and Giger, W. Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies // Sci. Total Environ. – 2007. – Vol. 372. – P. 361–371.
30. Lindsey, M. E., Meyer, M., and Thurman, E. M. Analysis of trace levels of sulfonamide and tetracycline antimicrobials in ground-water and surface water using solid-phase extraction and liquid chromatography/mass spectrometry // Anal. Chem. – 2001. – Vol. 73. – P. 4640–4646.
31. Göbel, A., Thomsen, A., McArdell, C. S., Joss, A., and Giger, W. Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment // Environ. Sci. Technol. – 2005. –Vol. 39. – P. 3981–3989.
32. Vieno, N. M., Tuhkanen, T., and Kronberg, L. Seasonal variationin the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water // Environ. Sci. Technol. – 2005. – Vol. 39. – P. 8220– 8226.
33. Xia, K., Bhandari, A., Das, K., and Pillar, G. Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids // J. Environ. Qual. – 2005. – Vol. 34, P. 91–104.
34. Yongjun Zhang, Sven-Uwe Geißen, Carmen Gal. Carbamazepine and diclofenac: Removal in wastewater treatment plants and occurrence in water bodies // Chemosphere. – 2008. – Vol. 73, Issue 8. – P. 1151–1161. https://doi.org/10.1016/j.chemosphere.2008.07.086
35. M. Clara, B. Strenn, N. Kreuzinger. Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of Carbamazepine in wastewater treatment and during groundwater infiltration // Water Res. – 2004 Feb. – Vol. 38(4). – P. 947–54. https://doi.org/10.1016/j.watres.2003.10.058.
36. ter Laak, T.L., Kooij, P.J.F., Tolkamp, H., Hofman, J. Different compositions of pharmaceuticals in Dutch and Belgian rivers explained by consumption patterns and treatment efficiency // Environmental Science and Pollution Research. – 2014. Vol. 21, No. 22. P. 12843–12855. https://doi.org/10.1007/s11356-014-3233-9
37. Hamed A. Qarni, Philip Collier, Juliette O’Keeffe, Joseph Akunna. Investigating the removal of some pharmaceutical compounds in hospital wastewater treatment plants operating in Saudi Arabia // Environmental Science and Pollution Research. – 2016. Vol. 23. P. 13003–13014. https://doi.org/10.1007/s11356-016-6389-7
38. Sesethu Vumazonke, Sandile Maswazi Khamanga, and Nosiphiwe Patience Ngqwala. Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province // Int J Environ Res Public Health. – 2020. Vol. 17(11). – P. 4067. https://doi.org/10.3390/ijerph17114067
39. HHS Public Access Author manuscript Circulation. Author manuscript; available in PMC 2017 September 07. Published in final edited form as: Circulation. 2017 March 07; 135(10): e146–e603. https://doi.org/10.1161/CIR.0000000000000485
40. Aubakirova B., Beisenova R., Boxall A.B.A. Prioritization of pharmaceuticals based on risks to aquatic environments in Kazakhstan // Integr. Environ. Assess. Manag. – 2017. – Vol. 13, No. 5. – P. 832–839.
Рецензия
Для цитирования:
Сатаева А., Камал А., Байменов А., Керим Т., Исаев Ж., Ким Д., Инглезакис В., Архангельски Е. МОНИТОРИНГ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ В ПОВЕРХНОСТНЫХ ВОДАХ ГОРОДА НУР-СУЛТАН И ЕГО ОКРЕСТНОСТЕЙ (РЕСПУБЛИКА КАЗАХСТАН). Вестник НЯЦ РК. 2022;(4):30-34. https://doi.org/10.52676/1729-7885-2022-4-30-34
For citation:
Sataeva A., Kamal A., Baimenov A., Kerim T., Isaev J., Kim D., Inglezakis V., Arkhangelski E. MONITORING OF MEDICINAL SUBSTANCES IN WASTE AND SURFACE WATER OF THE CITY OF NUR SULTAN AND ITS SURROUNDINGS (REPUBLIC OF KAZAKHSTAN). NNC RK Bulletin. 2022;(4):30-34. (In Russ.) https://doi.org/10.52676/1729-7885-2022-4-30-34